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The Nathan S. Kline Institute for Psychiatric Research

Stan Colcombe, Ph.D.

Stan Colcombe, Ph.D.

Research Scientist and Section Head
Center for Biomedical Imaging and Neuromodulation

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Stanley J. Colcombe, PhD, is an internationally renowned researcher in the aging domain, including cognitive and cardiovascular fitness interventions targeted to offset neurocognitive decline in aging adults. Dr. Colcombe pioneered research demonstrating that cardiovascular fitness interventions result in positive changes in cognitive performance, as well as the structure and function of the aging brain.  These findings have been replicated and extended several times and in many labs globally.  His current focus is the impact of cardiovascular fitness on neurocognitive function in middle age, and how this affects the development of the aging brain; this is the focus of his most recent R01 award. Additionally, Dr. Colcombe is intensively interested in utilizing alternative implementations of standard (archival) MRI imaging data to investigate both clinically and non-clinically relevant alterations in neurocognitive performance across the lifespan and various psychiatric disorders.

Select Publications

Colcombe, S. J., et al. (2004). "Cardiovascular fitness, cortical plasticity, and aging." Proceedings of the National Academy of Sciences of the United States of America 101(9): 3316-3321.

Biswal BB, Mennes M, Zuo XN, Gohel S, Kelly C, Smith SM, Beckmann CF, Adelstein JS, Buckner RL, Colcombe S, Dogonowski AM, Ernst M, Fair D, Hampson M, Hoptman MJ, Hyde JS, Kiviniemi VJ, Kötter R, Li SJ, Lin CP, Lowe MJ, Mackay C, Madden DJ, Madsen KH, Margulies DS, Mayberg HS, McMahon K, Monk CS, Mostofsky SH, Nagel BJ, Pekar JJ, Peltier SJ, Petersen SE, Riedl V, Rombouts SA, Rypma B, Schlaggar BL, Schmidt S, Seidler RD, Siegle GJ, Sorg C, Teng GJ, Veijola J, Villringer A, Walter M, Wang L, Weng XC, Whitfield-Gabrieli S, Williamson P, Windischberger C, Zang YF, Zhang HY, Castellanos FX, Milham MP (2010). Toward discovery science of human brain function. Proc Natl Acad Sci; 107(10):4734-9

Nooner KB, Colcombe SJ, Tobe RH, Mennes M, Benedict MM, Moreno AL, Panek LJ, Brown S, Zavitz ST, Li Q, Sikka S, Gutman D, Bangaru S, Schlachter RT, Kamiel SM, Anwar AR, Hinz CM, Kaplan MS, Rachlin AB, Adelsberg S, Cheung B, Khanuja R, Yan C, Craddock CC, Calhoun V, Courtney W, King M, Wood D, Cox CL, Kelly AM, Di Martino A, Petkova E, Reiss PT, Duan N, Thomsen D, Biswal B, Coffey B, Hoptman MJ, Javitt DC, Pomara N, Sidtis JJ, Koplewicz HS, Castellanos FX, Leventhal BL, Milham MP (2012). The NKI-Rockland Sample: A Model for Accelerating the Pace of Discovery Science in Psychiatry. Front Neurosci. 6:152.

Opitz A, Fox MD, Craddock RC, Colcombe S, Milham MP. An integrated framework for targeting functional networks via transcranial magnetic stimulation. Neuroimage. 2016 Feb 15;127:86-96.