Chris Goulbourne, Ph.D.

Chris Goulbourne, Ph.D.

Director of Electron Microscopy
Center for Dementia Research

Dr. Chris Goulbourne obtained his B.Sc. from Durham University and Ph.D. from Oxford University in molecular cell biology. He then went on to do an American Heart Association postdoctoral fellowship at UCLA where he specialized in electron microscopy techniques such as ultrastructural analysis, electron tomography, immunogold electron microscopy, correlative light and electron microscopy, and Nano Secondary Ion Mass Spectrometry (NanoSIMS). Since his postdoctoral fellowship he has managed electron microscopy laboratories at GlaxoSmithKline and Columbia University and now directs the facility at the Nathan Kline Institute to support investigators’ research.

Select Publications

  • D’Acunzo P, Ungania JM, Kim Y, Barreto BR, DeRosa S, Pawlik M, Canals-Baker S, Erdjument-Bromage H, Hashim A, Goulbourne CN, Neubert TA, Saito M, Sershen H, Levy E. Cocaine perturbs mitovesicle biology in the brain. J Extracell Vesicles. 2023 Jan;12(1):e12301. doi: 10.1002/jev2.12301. PMID: 36691887.

  • D’Acunzo P, Kim Y, Ungania JM, Pérez-González R, Goulbourne CN, Levy E. Isolation of mitochondria-derived mitovesicles and subpopulations of microvesicles and exosomes from brain tissues. Nat Protoc. 2022 Nov;17(11):2517-2549. doi: 10.1038/s41596-022-00719-1. Epub 2022 Aug 12. PMID: 35962195.

  • Lee JH, Yang DS, Goulbourne CN, Im E, Stavrides P, Pensalfini A, Chan H, Bouchet-Marquis C, Bleiwas C, Berg MJ, Huo C, Peddy J, Pawlik M, Levy E, Rao M, Staufenbiel M, Nixon RA. Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques. Nat Neurosci. 2022 Jun;25(6):688-701. doi: 10.1038/s41593-022-01084-8. Epub 2022 Jun 2. PMID: 35654956.

  • Lie PPY, Yoo L, Goulbourne CN, Berg MJ, Stavrides P, Huo C, Lee JH, Nixon RA. Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca2+ efflux and disrupted by PSEN1 loss of function. Sci Adv. 2022 Apr 29;8(17):eabj5716. doi: 10.1126/sciadv.abj5716. Epub 2022 Apr 29. PMID: 35486730.

  • D’Acunzo P, Pérez-González R, Kim Y, Hargash T, Miller C, Alldred MJ, Erdjument-Bromage H, Penikalapati SC, Pawlik M, Saito M, Saito M, Ginsberg SD, Neubert TA, Goulbourne CN, Levy E. Mitovesicles are a novel population of extracellular vesicles of mitochondrial origin altered in Down syndrome. Sci Adv. 2021 Feb 12;7(7):eabe5085. doi: 10.1126/sciadv.abe5085. PMID: 33579698.

  • Jiang H, Goulbourne CN, Tatar A, Turlo K, Wu D, Beigneux AP, Grovenor CR, Fong LG, Young SG. High-resolution imaging of dietary lipids in cells and tissues by NanoSIMS analysis. J Lipid Res. 2014 Oct;55(10):2156-66.

  • Goulbourne CN, Gin P, Tatar A, Nobumori C, Hoenger A, Jiang H, Grovenor CR, Adeyo O, Esko JD, Goldberg IJ, Reue K, Tontonoz P, Bensadoun A, Beigneux AP, Young SG, Fong LG. The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries. Cell Metab. 2014 May 6;19(5):849-60.

  • Jiang H, Favaro E, Goulbourne CN, Rakowska PD, Hughes GM, Ryadnov MG, Fong LG, Young SG, Ferguson DJ, Harris AL, Grovenor CR. Stable isotope imaging of biological samples with high resolution secondary ion mass spectrometry and complementary techniques. Methods. 2014 Jul 1;68(2):317-24.

  • Davies BS, Goulbourne CN, Barnes RH 2nd, Turlo KA, Gin P, Vaughan S, Vaux DJ, Bensadoun A, Beigneux AP, Fong LG, Young SG. Assessing mechanisms of GPIHBP1 and lipoprotein lipase movement across endothelial cells. J Lipid Res. 2012 Dec;53(12):2690-7.

  • Malhas A, Goulbourne C, Vaux DJ. The nucleoplasmic reticulum: form and function. Trends Cell Biol. 2011 Jun;21(6):362-73.