Chase A. Mackey, Ph.D.

Dr. Chase Mackey is a neuroscientist interested in how our brains segregate and combine information over time and space, and in turn allow us to perceive the world and communicate with others. He uses electrophysiological, behavioral, and computational methods to investigate this topic.

Dr. Mackey received his PhD from Vanderbilt University in 2022 after working in Ram Ramachandran’s laboratory, under the advisement of Drs. Ramachandran, Troy Hackett, Barbara Shinn-Cunningham, Randolph Blake, and Mark Wallace. This work established the relationship between single-neuron activity in the subcortical auditory system and complex signal processing in nonhuman primates, and leveraged this knowledge to further our understanding of noise-induced hearing loss.

At NKI, Dr. Mackey has developed skills in laminar multi-electrode recordings, which he is using to characterize the role of thalamic and cortical circuit dynamics in complex signal encoding and behavior. He characterizes these neuronal dynamics with Drs. Noelle O’Connell, Yoshi Kajikawa, and Annamaria Barczak, which feeds into an iterative biophysical modeling-neurophysiology loop by virtue of collaboration with Drs. Samuel Neymotin and Salvador Dura-Bernal. This work is then translated to humans in Dr. Stephan Bickel’s lab at Hofstra Northwell School of Medicine.