Carla Nasca, Ph.D.

Carla Nasca, Ph.D.

Research Scientist
Center for Dementia Research

Dr. Carla Nasca’s Epigenetics and System Neuroscience laboratory is working on an innovative model of epigenetic mechanisms of neuroplasticity to stress with a new angle on the communication between mitochondria and cell nuclei. Key to this framework is the pivotal mitochondrial metabolite L-acetyl-carnitine or LAC, which our group discovered as a novel epigenetic modulator of glutamatergic function and a promising therapeutic target for clinical endophenotypes of depression – a prodrome to Alzheimer’s Disease. Her laboratory also uses computational approaches together with emerging technologies to isolate patient-derived exosomes for identifying in vivo neural mechanisms of main CNS diseases (mood and cognitive disorders) and potential biomarkers of the responses to antidepressant candidates (LAC), drugs (ketamine) and brain stimulation (TMS).

Dr. Nasca’s research has been recognized with awards from the Blavatnik Foundation for Innovative Research, the Hope for Depression Research Foundation, the American Foundation for Suicide Prevention, the Brain and Behavior Research Foundation and the Falk Foundation for Transformative Research.

If interested in a Postdoctoral Research or Assistant Research Scientist position, please send email to or

Select Publications