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Dr. Ginsberg is a Research Scientist in NKI’s Center for Dementia Research (CDR) and a tenured Professor in the Departments of Psychiatry, Physiology and Neuroscience, New York University Grossman School of Medicine. His research interests include understanding molecular and cellular underpinnings of selective vulnerability within specific sets of forebrain neurons, particularly as they pertain to neurodegenerative, neuropsychiatric, and neurodevelopmental disorders. Dr. Ginsberg employs animal and cellular models of neurodegeneration and neurodevelopment, as well as human postmortem brain tissues for functional genomic and proteomic based studies relevant to understanding the pathobiology of aging, mild cognitive impairment (MCI), Alzheimer’s disease (AD), and Down syndrome (DS). The underlying hypothesis of his research is that individual cell types are likely to have unique patterns of gene and protein expression under normative conditions that are altered in pathological states, which drives subsequent neurodegeneration.
Dr. Ginsberg is trained in neuroanatomy, neuropathology, neurochemistry, and molecular & cellular neurobiology, including single population RNA sequencing (RNA-seq). He has been studying gene and protein expression profiles in the forebrain including vulnerable cell types within the basal forebrain, hippocampal formation, and neocortex for >30 years. Dr. Ginsberg has >30 years’ worth of experience with RNA amplification technology, >13 years’ worth of experience with RNA-seq technology, and >24 years’ worth of experience in proteomic profiling in animal and cellular models and human postmortem brains.
Current methodologies in the Ginsberg lab include bioinformatics, confocal laser scanning microscopy, dietary manipulations including calorie restriction (CR), CR mimetic delivery, high fat/high cholesterol diet delivery, and maternal choline supplementation (MCS), digital spatial profiling (DSP) transcriptomics/proteomics, electron microscopy, immunocytochemistry, in situ hybridization, microarray analysis, microaspiration via laser capture microdissection (LCM), Nanostring nCounter, Northern blotting, proteomics, real-time qPCR, RNA-seq, single cell/population cell RNA amplification, siRNA knockdown delivery, surgical manipulations including axotomy and intracerebral delivery paradigms, ELISA, and Western blotting.