The Smiley laboratory has a long-standing interest in understanding the neuropathology of schizophrenia, major depressive disorder, and related psychiatric diseases. A major focus has been on application of quantitative anatomical methods to postmortem human cerebral cortex, including measurements of cortical volumes, thickness, cell number, cell size, and other features. Parallel studies have looked at normal cortical organization in humans and in animal models, with an emphasis on the connections and topographical features that might be altered in human diseases. More recently we are extending our studies to animal models of brain development, to evaluate how early lesions influence the expression of psychiatric diseases, which often have their onset in adolescence or early adulthood.
Smiley JF, Bleiwas C, Canals-Baker S, Williams SZ, Sears R, Teixeira CM, Wilson DA, Saito M. Neonatal ethanol causes profound reduction of cholinergic cell number in the basal forebrain of adult animals. Alcohol. 2021 Aug 28;97:1-11. Epub ahead of print. PMID: 34464696.
Smiley JF, Bleiwas C, Masiello K, Petkova E, Betz J, Hui M, Wilson DA, Saito M. Effects of neonatal ethanol on cerebral cortex development through adolescence. Brain Struct Funct. 2019 Jun;224(5):1871-1884. PMID: 31049690; PMCID: PMC6565455.
Saito M, Smiley JF, Hui M, Masiello K, Betz J, Ilina M, Saito M, Wilson DA. Neonatal Ethanol Disturbs the Normal Maturation of Parvalbumin Interneurons Surrounded by Subsets of Perineuronal Nets in the Cerebral Cortex: Partial Reversal by Lithium. Cereb Cortex. 2019 Apr 1;29(4):1383-1397. PMID: 29462278; PMCID: PMC6418394.
Smiley JF, Saito M, Bleiwas C, Masiello K, Ardekani B, Guilfoyle DN, Gerum S, Wilson DA, Vadasz C. Selective reduction of cerebral cortex GABA neurons in a late gestation model of fetal alcohol spectrum disorder. Alcohol. 2015 Sep;49(6):571-80. PMID: 26252988; PMCID: PMC4554880.
Smiley JF, Konnova K, Bleiwas C. Cortical thickness, neuron density and size in the inferior parietal lobe in schizophrenia. Schizophr Res. 2012 Apr;136(1-3):43-50. PMID: 22304984.
Smiley JF, Rosoklija G, Mancevski B, Mann JJ, Dwork AJ, Javitt DC. Altered volume and hemispheric asymmetry of the superficial cortical layers in the schizophrenia planum temporale. Eur J Neurosci. 2009 Aug;30(3):449-63. PMID: 19656176; PMCID: PMC2771288.