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The Nathan S. Kline Institute for Psychiatric Research

Jean-Pierre Lindenmayer, M.D.

Jean-Pierre Lindenmayer, M.D.

Director, Psychopharmacology Research Unit
Manhattan Psychiatric Center / NKI

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Dr. Jean-Pierre Lindenmayer is Director of the Psychopharmacology Research Program at Manhattan Psychiatric Center - Nathan Kline Institute for Psychiatric Research, Clinical Director of the Manhattan Psychiatric Center, and Clinical Professor, Department of Psychiatry at New York University School of Medicine.

Dr. Lindenmayer has conducted extensive clinical research, first as Director of the Schizophrenia Research Program at the Bronx Psychiatric Center, Albert Einstein College of Medicine, before joining the Manhattan Psychiatric Center.

Dr. Lindenmayer’s particular interest in research has included the development of new pharmacological and neurocognitive treatments for schizophrenia patients. He has conducted a wide range of NIMH funded studies in the area of suboptimal responding schizophrenia, studies of early Phase II proof-of-concept trials of new antipsychotics, studies of metabolic side effects of atypical antipsychotics, and neurocognitive interventions for cognitive deficits in schizophrenia. In collaboration with other Principal Investigators, he has been involved in using a broad range of investigative tools, including psychopathological and cognitive assessments, functional imaging, and genotyping. He has significantly contributed to the development of the Positive and Negative Syndrome Scale (PANSS and SCI-PANSS), which has become a widely and internationally accepted instrument for the assessment of schizophrenia symptoms. He has developed the InterSept Scale for Suicidal Ideation (ISST), an instrument to measure suicidal thinking in patients with schizophrenia, and the PANSS Excitement Scale. He has introduced the syndromal approach and measurement of schizophrenia psychopathology using the five PANSS derived Factor subscales. On the neurocognitive side, Dr. Lindenmayer was one of the first authors to introduce a systematic program of computer based neurocognitive remediation for patients with chronic schizophrenia.

Dr. Lindenmayer’s work has led to numerous publications and articles in leading scientific journals, and several books as well as book chapters and presentations at national and international meetings.