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The Nathan S. Kline Institute for Psychiatric Research

Center for Dementia Research (CDR)

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Epigenetics and System Neuroscience Laboratory

Lab Name
#528cb4
Head of Lab
Visiting Research Scientist
Assistant Research Scientist

The Epigenetics and System Neuroscience laboratory headed by Dr. Carla Nasca is working on an innovative model of epigenetic mechanisms of neuroplasticity to stress with a new angle on the communication between mitochondria and cell nuclei. Key to this framework is the pivotal mitochondrial metabolite L-acetyl-carnitine or LAC, which our group discovered as a novel epigenetic modulator of glutamatergic function and a promising therapeutic target for clinical endophenotypes of depression – a prodrome to Alzheimer’s Disease. Her laboratory also uses computational approaches together with emerging technologies to isolate patient-derived exosomes for identifying in vivo neural mechanisms of main CNS diseases (mood and cognitive disorders) and potential biomarkers of the responses to antidepressant candidates (LAC), drugs (ketamine) and brain stimulation (TMS).

If interested in a Postdoctoral Research or Assistant Research Scientist position, please email to carla.nasca@nyulangone.org or carla.nasca@nki.rfmh.org