Clozapine for the Prevention of Violence in Schizophrenia: A Randomized Clinical Trial [1]
Two-hundred and eighty individuals with schizophrenia who have a recent history of violent acts will be randomized in this 2-arm, parallel-group, 24-week, open-label, 7-site clinical trial to examine the effects of treatment with clozapine vs. antipsychotic treatment as usual (TAU) for reducing the risk of violent acts in real-world settings.
- DSM-5 diagnosis of schizophrenia or schizoaffective disorder
- Committed a minor or serious act of violence as measured by the MCVI in the last six months
- 18 to 65 years old
- Appropriate for treatment with either clozapine or TAU
Two-hundred and eighty individuals with schizophrenia who have a recent history of violent acts will be randomized in this 2-arm, parallel-group, 24-week, open-label, 7-site clinical trial to examine the effects of treatment with clozapine vs. antipsychotic treatment as usual (TAU) for reducing the risk of violent acts in real-world settings.
For more information about this study, please contact Seth Eaton, research coordinator, at 646-766-5864 or Seth.Eaton@omh.ny.gov [2].
- An unstable or serious medical or neurological condition
- A history of intolerance/allergy to clozapine
- A history of intellectual impairment
- Pregnant or lactating women; women who are able to become pregnant but who are not willing to use effective methods of birth control.