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Home > Clozapine for the Prevention of Violence in Schizophrenia: A Randomized Clinical Trial

Clozapine for the Prevention of Violence in Schizophrenia: A Randomized Clinical Trial [1]

Two-hundred and eighty individuals with schizophrenia who have a recent history of violent acts will be randomized in this 2-arm, parallel-group, 24-week, open-label, 7-site clinical trial to examine the effects of treatment with clozapine vs. antipsychotic treatment as usual (TAU) for reducing the risk of violent acts in real-world settings.

Study Length: 
24 weeks
Disorder/Condition: 
Schizophrenia
Inclusion Criteria: 
  • DSM-5 diagnosis of schizophrenia or schizoaffective disorder
  • Committed a minor or serious act of violence as measured by the MCVI in the last six months
  • 18 to 65 years old
  • Appropriate for treatment with either clozapine or TAU
Study Title (brief): 
Clozapine for the Prevention of Violence in Schizophrenia: A Randomized Clinical Trial
Study Description (brief): 

Two-hundred and eighty individuals with schizophrenia who have a recent history of violent acts will be randomized in this 2-arm, parallel-group, 24-week, open-label, 7-site clinical trial to examine the effects of treatment with clozapine vs. antipsychotic treatment as usual (TAU) for reducing the risk of violent acts in real-world settings.

Study Contact: 

For more information about this study, please contact Seth Eaton, research coordinator, at 646-766-5864 or Seth.Eaton@omh.ny.gov [2].

Exclusion Criteria: 
  • An unstable or serious medical or neurological condition
  • A history of intolerance/allergy to clozapine
  • A history of intellectual impairment
  • Pregnant or lactating women; women who are able to become pregnant but who are not willing to use effective methods of birth control.
Study Location: 
Manhattan Psychiatric Center, 102 Rivers Edge Road, New York, NY 10035 AND Manhattan Psychiatric Center Outpatient Clinic, 163 West 125th Street, New York, NY 10027

Source URL:https://www.nki.rfmh.org/content/clozapine-prevention-violence-schizophrenia-randomized-clinical-trial

Links
[1] https://www.nki.rfmh.org/content/clozapine-prevention-violence-schizophrenia-randomized-clinical-trial [2] mailto:Seth.Eaton@omh.ny.gov