Dr. Linn's educational and training background is in Zoology and Physical Anthropology (U. of Michigan, BS in Anthropology-Zoology; Rutgers University, PhD in Physical Anthropology, specializing in Primatology). He has have a longstanding interest in nonhuman primate gonadal hormone influences on social and sexual behavior, nonhuman primate behavioral psychopharmacology relating to schizophrenia, and nonhuman primate neurophysiology and neuromodulation. At NKI, Dr. Linn first worked under Ken Lifshitz, who was studying effects and side-effects of antipsychotics, antidepressants, and other pharmacological manipulations on Cebus monkey behavior and neurophysiology as a model for treatment development. He then worked in Dan Javitt’s group developing nonhuman primate models of schizophrenia using NMDA receptor antagonists such as PCP. They also evaluated the reversibility of symptoms using NMDA receptor agonists such as glycine or D-serine, and performed PET imaging and neurophysiological studies using methods including prepulse inhibition and mismatch negativity. Dr. Linn has also been involved in FDA GLP toxicity studies for compounds such as glycine and D-serine. Currently, he is working in Charlie Schroeder’s group and has contributed to projects studying the effects of different types of neuromodulation on nonhuman primate fMRI and neurophysiological measures of brain activity. These neuromodulation modalities include designer receptors exclusively activated by designer drugs (DREADDs), transcranial focused ultrasound (tFUS), transcranial magnetic stimulation (TMS), and transcranial alternating and direct current stimulation (tACS/tDCS).
Opitz A., Falchier A., Yan C.G., Yeagle E.M., Linn G.S., Megevand P., Thielscher A., Ross D.A., Milham M.P., Mehta A.D., Schroeder C.E.: Spatiotemporal structure of intracranial electric fields induced by transcranial electric stimulation in humans and nonhuman primates. Sci Rep. 6: 31236, 2016.
Linn G.S.: Neuroleptic-induced acute dystonia and tardive dyskinesia in primates. In: Animal Models of Movement Disorders, LeDoux, M. (Ed), Elsevier, pp 725-733, 2004.
Linn G.S., O'Keeffe R.T., Lifshitz K., Schroeder C., Javitt D.C.: Behavioral effects of orally administered glycine in socially housed monkeys chronically treated with phencyclidine. Psychopharmacology 192: 27-38, 2007.
Carosi M., Linn G.S.; Visalberghi E.: Sexual behavior and breeding system of tufted capuchin monkeys (Cebus apella). In: Advances in the Study of Behavior, 35, Slater P., Snowdon C., Roper T., Brockman H. J., Naguib M. (Eds), Academic Press, pp 105-149, 2005.
Linn G.S., Negi S.S., Gerum S.V., Javitt D.C.: Reversal of phencyclidine-induced prepulse inhibition deficits by clozapine in monkeys. Psychopharmacology 169: 234-239, 2003.