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The Nathan S. Kline Institute for Psychiatric Research

Virtual reality-based training for aggressive behaviors in individuals with severe mental illness: a feasibility and proof of concept study

This comparator study will explore the feasibility and efficacy of the novel TRIPP™ Virtual Reality (TRIPP VR) device, which presents to inpatients computer-generated images of soothing and colorful figures inducing a mindfulness state and its effect on impulsive aggressive behavior.  Participants will be randomized to the Virtual Reality and Mobile app groups and receive 3 sessions of mindfulness training each week for a total of 18 sessions (up to 180 minutes).

Study Length: 
Six weeks
Disorder/Condition: 
Schizophrenia
Inclusion Criteria: 
  • Male and female patients
  • 18-65 years of age
  • Diagnosis: Schizophrenia or Schizoaffective Disorder
  • Documented assault in the past year or a score of at least 5 on the Life History of Aggression (LHA)
Study Title (brief): 
Virtual reality-based training for aggressive behaviors in individuals with severe mental illness: a feasibility and proof of concept study
Study Description (brief): 

This comparator study will explore the feasibility and efficacy of the novel TRIPP™ Virtual Reality (TRIPP VR) device, which presents to inpatients computer-generated images of soothing and colorful figures inducing a mindfulness state and its effect on impulsive aggressive behavior.  Participants will be randomized to the Virtual Reality and Mobile app groups and receive 3 sessions of mindfulness training each week for a total of 18 sessions (up to 180 minutes).

Study Contact: 

Anzalee Khan, PhD, Co-Principal Investigator at 646-672-6005 or Anzalee.Khan@nki.rfmh.org

Exclusion Criteria: 
  • Non-English speaking
  • Substance abuse one month prior to baseline
  • Clinically unstable
  • History of traumatic brain disorder
Study Location: 
Manhattan Psychiatric Center, Ward's Island Complex, NY